Selective Th2 Suppressor Atlas

Local review index — every artifact, linked with relative paths. Open this file in a browser to click through the analysis independently.

Start here

The dashboard (self-contained), the plain-language synthesis, and the independent-review report.

Figures

The 2D arm plane (headline) and the known-regulator recall overlay.

Result tables

Ranked shortlist (known vs novel), tiered selective list, per-condition selectivity, and the QC audit of the high-confidence set.

Intermediate data

Reconstructed arm scores, per-gene annotations, merged candidates, and the pulled h5ad QC columns.

Mechanism dossiers

Per-candidate agentic dossier: hypothesis, mechanism, evidence, proposed experiment, and the adversarial review.

AHSA1.md 6 KB
ARNT.md 6 KB
ELAVL1.md 6 KB
GPATCH8.md 6 KB
KDM2A.md 7 KB
MIA2.md 6 KB
MPG.md 6 KB
RAB21.md 6 KB
SSR1.md 6 KB
STK35.md 6 KB

Analysis code (reproducible)

01 arms -> 02 annotations -> 03 credibility -> 04 score -> 05 dashboard -> 06 dossiers -> 07 QC audit -> 08 this index.

Inputs (from the Marson-lab repo)

The external Th2/Th1 signature, known-regulator calibration set, and the supplementary QC tables.

Ota_Th2vsTh1_DE_results.csv 3.9 MB
th1_th2_known_regulators.yaml 0 KB
DE_stats.suppl_table.csv 5.3 MB
guide_kd_efficiency.suppl_table.csv 13.3 MB
Lambert_2018_HumanTF.csv 97 KB
donor_info.csv 0 KB

All paths are relative to this file. CSV/parquet open in your spreadsheet tool or a notebook; .md and .py open as text; .svg/.png in the browser. Generated from the outputs/ and notebooks/ directories.